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Pre-Prints

  1. Lee S, Zhao S, Chen X, Zhu L, Joseph J, Agus E, Barooj S, Mary HB, Shah P, Slaughter K, Cheung K, Luo NJ, Gao J, Lee D, Karp JM, Joshi N. An injectable in situ crosslinkable platform for ultra-long-acting delivery of hydrophilic therapeutics. bioRxiv. November 2023. https://doi.org/10.1101/2023.11.04.565631. Link

  2. Joseph J, Baby HM, Quintero JR, Kenney D, Mebratu YA, Bhatia E, Shah P, Swain K, Kaur S, Li XL, Mwangi J, Snapper O, Nair R, Agus E, Ranganathan S, Kage J, Gao J, Luo JN, Yu A, Douam F, Tesfaigzi Y, Karp JM, Joshi N. A drug-free pathogen capture and neutralizing nasal spray to prevent emerging respiratory infections. bioRxiv. October 2023. https://doi.org/10.1101/2023.10.02.560602. Link

Peer-Reviewed Publications

  1. Banerjee A, Lee D, Jiang C, Wang R, Kutulakos ZB, Lee S, Gao J, Joshi N. Progress and challenges in intravesical drug delivery. Expert Opinions on Drug Delivery. January 2024. https://doi.org/10.1080/17425247.2024.2307481. Link

  2. Liu, H, Chen, W, Wu, G, Zhou, J, Liu, C, Tang, Z, Huang, X, Gao, J, Xiao, Y, Kong, N, Joshi, N, Cao, Y, Abdi, R, and Tao, W. Glutathione-scavenging nanoparticle-mediated PROTACs delivery for targeted protein degradation and amplified antitumor effects. Advanced Science. April 2023, 10(16). https://doi.org/10.1002/advs.202207439. Link 

  3. Gao, J, Xia, Z, Vohidova, D, Joseph, J, Luo, JN, and Joshi, N. Progress in non-viral localized delivery of siRNA therapeutics for pulmonary diseases. Acta Pharmaceutica B. April 2023, 13(4). https://doi.org/10.1016/j.apsb.2022.07.010. Link

  4. Gao, J, Karp, JM, Langer, R, and Joshi, N. The future of drug delivery. Chemistry of Materials. January 2023, 35(2). https://doi.org/10.1021/acs.chemmater.2c03003. Link 

  5. Joseph, J, Baby, HM, Zao, S, Xi, L, Cheung, K, Swain, K, Agus, E, Ranganathan, S, Gao, J, Luo, JN, and Joshi, N. Role of bioaerosol in virus transmission and material based countermeasures. Exploration. May 2022, 2(6). https://doi.org/10.1002/EXP.20210038. Link

  6. Aday S, Li W, Karp JM, Joshi N. An in vitro blood brain barrier model to study the penetration of nanoparticles. Bio-protocol. 2022 Feb 20;12(4). https://doi.org/10.21769/BioProtoc.4334. Link

  7. Gao J, Xia X, Mary HB, Joseph J, Luo JN, Joshi N. Overcoming barriers for intra-articular delivery of disease-modifying osteoarthritis drugs. Trends in Pharmacological Sciences. March 2022;43(3). https://doi.org/10.1016/j.tips.2021.12.004. Link

  8. Xiao Y, Tang Z, Huang X, Joseph J, Chen W, Liu C, Zhou J, Kong N, Joshi N, Du J, Tao W. Glucose-responsive oral insulin delivery platform for one treatment a day in diabetes. Matter. 2021 Oct 6;4(10). https://doi.org/10.1016/j.matt.2021.08.011. Link

  9. Zhao J, Zhang Z, Joseph J, Zhang X, Ferdows BE, Patel DN, Chen W, Banfi G, Molinaro R, Cosco D, Kong N, Joshi N, Farokhzad OC, Corbo C, Tao W. Biomaterials and nanomedicine for bone regeneration: Progress and future prospects. Exploration. 2021 Oct 30. https://doi.org/10.1002/EXP.20210011. Link

  10. Chen W, Liu C, Ji X, Joseph J, Tang Z, Ouyang J, Xiao Y, Kong N, Joshi N, Farokhzad O, Tao W, Xie T. Stanene‐based nanosheets for β‐elemene delivery and ultrasound‐mediated combination cancer therapy. Angewandte Chemie. 2021 Mar 22;60(13). https://doi.org/10.1002/anie.202016330 Link

  11. Jiang L, Jung S, Zhao J, Kasinath V, Ichimura T, Joseph J, Fiorina P, Liss AS, Shah K, Annabi N, Joshi N, Akama TO, Bromberg JS, Kobayashi M, Uchimura K, Abdi R. Simultaneous targeting of primary tumor, draining lymph node, and distant metastases through high endothelial venule-targeted delivery. Nanotoday. 2021 Feb;36. DOI: https://doi.org/10.1016/j.nantod.2020.101045. Link

  12. Li W, Qiu J, Li X-L, Aday S, Zhang J, Conley G, Xu J, Joseph J, Lan H, Langer R, Mannix R, Karp JM, Joshi N. BBB pathophysiology independent delivery of siRNA in traumatic brain injury. Science Advances. 2021 Jan 1;7(1). DOI: 10.1126/sciadv.abd6889. Link Press Coverage: EurekaAlert Reuters Genengnews NIH

  13. Shanmugam T, Joshi N, Kaviratna A, Ahamad N, Bhatia E, Banerjee R. Aerosol delivery of paclitaxel-containing self-assembled nanocochleates for treating pulmonary metastasis: an approach supporting pulmonary mechanics. ACS Biomaterials Science and Engineering. 2020 Dec 21;7(1). DOI: 10.1021/acsbiomaterials.0c01126. Link

  14. Rogers OC, Antony L, Levy O, Joshi N, Simons BW, Dalrymple SL, Rosen DM, Pickering A, Lan H, Kuang H, Ranganath S, Zheng L, Karp JM, Howard SP, Denmeade SR, Issacs JT, Brennen WN. Microparticle encapsulation of a prostate-targeted biologic for the treatment of liver metastases in a preclinical model of castration-resistant prostate cancer. Molecular Cancer Therapeutics. 2020 Sep 21;19(11). DOI: 10.1158/1535-7163.MCT-20-0227. Link

  15. Zhao S, Karp JM, Joshi N. Toxin mediated siRNA delivery. Trends in Pharmacological Sciences. 2020 Aug;41(8): 511-13. Link

  16. Shanmugam T, Joshi N, Ahmad N, Deshmukh A, Banerjee R. Enhanced absorption, and efficacy of oral self-assembled paclitaxel nanocochleates in multi-drug resistant colon cancer. International Journal of Pharmaceutics. 2020 Aug 30;586:119482. DOI: 10.1016/j.ijpharm.2020.119482. Link

  17. Dhyani M, Joshi N, Bemelman WA, Gee MS, Yajnik V, D’Hoore A, Traverso G, Donowitz M, Mostoslavsky G, Lu TK, Lineberry N, Niessen HG, Peer D, Braun J, Delaney CP, Dubinsky MC, Guillory AN, Pereira M, Shtraizent N, Honig G, Polk DB, Hurtado-Lorenzo A, Karp JM, Michelassi F. Challenges in IBD Research: Novel Technologies. Inflammatory Bowel Disease. 2019;25(2): S24-S30. Link

  18. Balakrishnan B, Joshi N, Thorat K, Kaur S, Chandan R, Banerjee R. A tumor responsive self-healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapy. Journal of Materials Chemistry B. 2019;7: 2920-25. Link

  19. Fries CA, Lawson SD, Wang LC, Slaughter KV, Vemula PK, Dhayani A, Joshi N, Karp JM, Rickard RF, Gorantla VS, Davis MR. Graft-implanted, enzyme responsive, tacrolimus-eluting hydrogel enables long-term survival of orthotopic porcine limb vascularized composite allografts: a proof of concept study. PLoS ONE. 2019 Jan 24;14(1): e0210914. DOI: 10.1371/journal.pone.0210914. Link

  20. Rosenblum D, Joshi N, Tao W, Karp JM, Peer D. Progress and challenges towards targeted delivery of cancer therapeutics. Nature Communications. 2019;9. DOI: 10.1038/s41467-018-03705-y. Link Press Coverage: EuerkaAlert

  21. Joshi N. Can nanotechnology hit the spot in aerosol based drug delivery for lung disorders? Therapeutic Delivery. 2018 Mar 2;9(4): 233-36. Link

  22. Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter K, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda O, Levy O, Gravallese EM, Aliprantis A, Ermann JE, Karp JM. Towards an arthritis flare-responsive drug delivery system. Nature Communications. 2018;1275. DOI: 10.1038/s41467-018-03691-1. Link Press Coverage: Science Daily Fierce Biotech Journal of American Medical Association Nature Reviews Rheumatology

  23. Joshi N. Nanotechnology enabled inhalation of bio-therapeutics for pulmonary diseases: design considerations and challenges. Current Pathobiology Reports. 2018 Oct 24;6: 225-231. Link

  24. Tong Z, Martyn K, Yang A, Yin X, Mead BE, Joshi N, Sherman N, Langer RS, Karp JM. Towards a defined ECM and small molecule based monolayer culture system for the expansion of mouse and human intestinal stem cells. Biomaterials. 2018 Feb;154: 60-73. Link

  25. Joshi N, Kaur S, Banerjee R. Advances in sub-micron particle based aerosol strategies for efficient systemic delivery of therapeutic agents. Current Pharmaceutical Design. 2016;22(17): 2470-80. Link

  26. Levy O, Brennen WN, Han E, Rosen DM, Musabeyezu J, Safaee H, Ranganath S, Ngai J, Heinelt M, Milton Y, Wang H, Bhagchandani SH, Joshi N, Bhowmick N, Denmeade SR, Isaacs JT, Karp JM. A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer. Biomaterials. 2016 Jun;91: 140-50. Link

  27. Sajith AM, Khader KKA, Joshi N, Reddy MN, Padusha MSA, Nagaswarupa HP, Joy MN, Bodke YD, Karuvalam RP, Banerjee R, Muralidharan A, Rajendra P. Design, synthesis and structure–activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents. European Journal of Medicinal Chemistry. 2015 Jan 7;89: 21-31. Link

  28. Joshi N, Shirsath N, Singh A, Joshi K, Banerjee R. Endogenous lung surfactant inspired pH responsive nanovesicle aerosols: Pulmonary compatible and site-specific drug delivery in lung metastases. Scientific Reports. 2014;4. DOI:10.1038/srep07085. Link

  29. Balakrishnan B, Joshi N, Banerjee R. Self-crosslinked oxidized alginate/gelatin hydrogel as injectable, adhesive biomimetic scaffolds for cartilage regeneration. Acta Biomaterialia. 2014 Aug;10(8): 3650-63. Link

  30. Joshi N, Shanmugam T, Deshmukh A, Banerjee R. Apoptotic cascade inspired lipid nanovesicles show synergism with encapsulated paclitaxel in chemoresistant colon carcinoma. Nanomedicine (London). 2014;9(12): 1789-1805. Link

  31. Balakrishnan B, Joshi N, Banerjee R. Borate aided Schiff’s base formation yields in situ gelling hydrogels for cartilage regeneration. Journal of Materials Chemistry B. 2013;1: 5564-77. Link

  32. Joshi N, Saha R, Shanmugam T, More P, Balakrishnan B, Banerjee R. Carboxymethyl chitosan grafted lipid vesicles: hybrid nanoblanket for oral delivery of paclitaxel. Biomacromolecules. 2013;14(7): 2272-82. Link

  33. Thakur A, Joshi N, Shanmugam T, Banerjee R. Proapoptotic miltefosine nanovesicles show synergism with paclitaxel: Implications in glioblastoma multiforme therapy. Cancer Letters. 2013 Jul 1;334(2): 274-83. Link

  34. Joshi N, Kaviratna A, Banerjee R. Multi trigger responsive, surface active lipid nanovesicle aerosols for improved efficacy of paclitaxel in lung cancer. Integrative Biology. 2013 Jan; 5(1): 239-48. Link

  35. Joshi N, Shanmugam T, Kaviratna A, Banerjee R. Proapoptotic lipid nanovesicles: synergism with paclitaxel in human lung adenocarcinoma A549 cells. Journal of Controlled Release. 2011 Dec 20; 156(3): 413-20. Link

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